A dose auspicious and MacKinnon study the little passage aisle of cell membrane The helpful mankind finds out about such diseases as the heart, kidney, muscle and nervous system,etc. greatly
Compile Yijun Chen / scientist of comprehensive dispatch American A doses of auspicious and MacKinnon because of their study on little passage aisle of cell membrane, let the mankind understand to such diseases as the heart, kidney, muscle and nervous system,etc. greatly, get two O O Nobel chemistry Prize special honours of three years together on the seventh.
Relatively, A dose auspicious and MacKinnon is young with Nobel scientific all previous winner looks of reward, and their discover that all finish in recent years, let scientific circles known to some diseases further.
Sweden royal academy of sciences point out, teach on American 54 years old biochemistry, Johns Hopkins University of medical college studying housing A dose auspicious, obtain the award because had passways that could supply water and pass in and out to discover the cell membrane in 1988; Roek 47 years old ties professor of China Hughes medical research center MacKinnon Huo of the university tight strikingly, is it pierce through passway structure and function of cell membrane obtain the great achievement of studying to bring ionization son transporting.
Sweden royal academy of sciences say two research of winner contribute and show, the contemporary biochemical study on basic course of life has already developed to the level of the garden, two people can divide 10 million Swedish Krones equally ( About new Taiwan dollars of 44,340,000 yuan) Bonus.
Scientific circles put forward will it be middle period the 19th century human cell should have moisture transport theory of channel. A isolated a kind of protein in the cell membrane in since auspicious 88, through the research of about one year, just find this is the water passway where scientific circles looked for for a long time. The discoveries of this passway of proteins, opening the mankind will carry on cell water passway all serial biochemistry, physiology and gate of gene studies to the bacterium, plant and mammal.
Because of A doses of auspicious discovery, researcher can track moisture son pierces through the way of the cell membrane, understand other small member or unable to pierce through cell membrane is only permitted reason, son of moisture, ion. The heat wave in this summer of Europe causes several tens of thousands of deaths, it may be unable to keep the moisture balanced and dehydrating to have something to do with with the human body; A doses of auspicious discovery is it prevent similar to happen unfortunately to help perhaps.
MacKinnon makes remarkable contribition to the thing that the ion passway of cell membrane is studied. Sweden royal academy of sciences with ' shock global research circle ', describe he confirm cell potassium passway achievement, space of structure in 1998, let mankind can understand ion can accept different cell signal but situation flowing of the passway of the switch in this. The ion passway is extremely important to the function of nervous system and muscle. After the ion passway on the nerve cell surface is received and come from the chemical signal near the similar cell to open, will produce the so-called movement electric potential, in (per 1,000 of several milliseconds Second) Start the switch of other ion passway inside, and then transmit the electronic pulse prolonging on the nerve cell surface.
Small passage aisle Key role of the biological phenomena
(reporter Guo YiJun / the report of Taibei) Nobel chemistry Prize is awarded to the great discovery persons of ' water passway ' and ' the ion passway ' this year, the research of these two kinds of passways is the biochemical category, and apply to the medical field mainly, the persons who grow medical science at home point out, water passway and ion passway are all formed by protein, responsible for adjusting and controlling the moisture son and ion in the organism to pass in and out separately, if lack water passway, the water yield that the human body discharges every day will be usual 12 times, if the ion passway, may knowing to is it suspend suddenly to jump, prominent they key role that act among biological phenomena.
Biomedical assistant researcher of research institute Xie RuJi of Academia Sinica points out, the ion passway finds as far back as the end of the 19th century the most, the passway that the scientist formed known cell membrane some proteins made the specific ion pass at that time, for example the heart is the beating of machinery, does not need to control through the brain, so long as the protein in the cell and calcium ion work, in the calcium ion through letting the heart be shrunk.
Can only attack by innuendo to the pinpoint ion passway in scientific circles for a long time, award-winning MacKinnon succeeds in separating this year firstly from the cell the scientist coming out in purification on ' the potassium ion passway ', and see structure of it clearly with X-rays, RuJi Xie point out scientific circles in the past think water diffusion of the cell mainly leaning against the function of permeating, get 195 O times find some special passway just, can by energy consumption less, speed very fast way pass by the moisture son, but scientific circles has been unable to separate water passway independently to look over and study carefully all the time, the award-winning A dose auspicious to is it succeed in first people come out to separate water passway to succeed in.
Xie RuJi points out, because of the existence of water passway, the human body could recycle water, the adult will discharge 1.5 liters of water every day on average, if have water passway, Iraq it will will be it discharge liter of waters to take.